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Sep 27, - Usually, the first sign of arthritis in the thumb is pain, tenderness, and stiffness. You're most You might be left with a lingering ache. A high. May 15, - When the tendons around the thumb get inflamed, you might develop tendonitis which will lead to pain around the thumb joint to develop. Carpal tunnel syndrome is another potential source of thumb joint pain. Some of the Symptoms associated with CTS are thumb pain, tingling or numbness.